RNA Details
Disease Name
liver cirrhosis
Tissue
liver
RNA Symbol
Septin9
RNA ID
RNA Type
mRNA
Alteration Pattern
sept9 methylation
Species
mus musculus
Detection Methods
qRT-PCR; immunohistochemistry etc.
Target
44448
Pathway
NA
PubMed ID
Title
Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis
Year
2017
Function
Epigenetic repression of smad7 promotes the phosphorylation of smad2 and smad3 that may be an important molecular mechanism for perpetuated hsc activation and liver fibrosis.